My left ankle and lower leg area is really swollen but my right is completely normal. I'm 14 and a long distance runner but I've been biking instead of running for the past 2 days because of knee pain. I've been wrapping my knee so could that be a cause of swelling if the wrap was too tight? The swelling is on the same side of the bad knee. Could it be from tying that shoe too tight? Can taking an anti inflammatory (naproxen) cause swelling?